InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fyco1

Summary

InnateDB Protein

IDBP-206473.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fyco1

Protein Name

FYVE and coiled-coil domain containing 1

Synonyms

2810409M01Rik; Mem2; RUFY3; ZFYVE7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081764

InnateDB Gene

IDBG-206471 (Fyco1)

Protein Structure

UniProt Annotation

Function

May mediate microtubule plus end-directed vesicle transport. {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle, autophagosome {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart and testis. Expressed in the eye lens. {ECO:0000269PubMed:12461651, ECO:0000269PubMed:21636066}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0072383	plus-end-directed vesicle transport along microtubule

Cellular Component

GO:0005764	lysosome
GO:0005770	late endosome
GO:0005776	autophagic vacuole
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle