Version 5.4
Mus musculus Protein: Ptpra
Summary
InnateDB Protein IDBP-206476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptpra
Protein Name protein tyrosine phosphatase, receptor type, A
Synonyms Ptpa; Ptpalpha; Rptpalpha; Rptra; Rptralpha;
Species Mus musculus
Ensembl Protein ENSMUSP00000076533
InnateDB Gene IDBG-206474 (Ptpra)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Widely expressed. Highest expression in brain and kidney. {ECO:0000269PubMed:1932742, ECO:0000269PubMed:2162042, ECO:0000269PubMed:2166945}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0008286 insulin receptor signaling pathway
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:97808
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR016336 Receptor tyrosine-protein phosphatase, alpha/epsilon-type
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PRINTS PR00700
PIRSF PIRSF002006
SMART SM00194
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P18052
PhosphoSite PhosphoSite-P18052
TrEMBL Q3TRY9
UniProt Splice Variant
Entrez Gene 19262
UniGene Mm.224246
RefSeq NP_033006
MGI ID 1YFO
MGI Symbol Ptpra
OMIM
CCDS CCDS16743
HPRD
IMGT
EMBL AK162387 AL731707 CH466519 L13607 M36033 M36034 Z23054 Z23055
GenPept AAA39448 AAA39449 BAE36887 CAA80589 CAA80590 CAM13265 EDL28272

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca