InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptpra

Summary

InnateDB Gene

IDBG-206474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpra

Gene Name

protein tyrosine phosphatase, receptor type, A

Synonyms

Ptpa; Ptpalpha; Rptpalpha; Rptra; Rptralpha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027303

Encoded Proteins

IDBP-206476

protein tyrosine phosphatase, receptor type, A

IDBP-206478

protein tyrosine phosphatase, receptor type, A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132670:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:130450278-130554026

Strand

Forward strand

Band

Transcripts

ENSMUST00000077303	ENSMUSP00000076533
ENSMUST00000028769	ENSMUSP00000028769

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006470	protein dephosphorylation
GO:0008286	insulin receptor signaling pathway
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation