InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Car4

Summary

InnateDB Protein

IDBP-206483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Car4

Protein Name

carbonic anhydrase 4

Synonyms

AW456718; Ca4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099483

InnateDB Gene

IDBG-206479 (Car4)

Protein Structure

UniProt Annotation

Function

Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004089	carbonate dehydratase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006730	one-carbon metabolic process
GO:0006885	regulation of pH
GO:0015670	carbon dioxide transport
GO:0015701	bicarbonate transport
GO:0042493	response to drug
GO:0048513	organ development
GO:0048545	response to steroid hormone

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0016529	sarcoplasmic reticulum
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane
GO:0031362	anchored component of external side of plasma membrane
GO:0031526	brush border membrane
GO:0042383	sarcolemma
GO:0046658	anchored component of plasma membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome