InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Car4

Summary

InnateDB Gene

IDBG-206479.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Car4

Gene Name

carbonic anhydrase 4

Synonyms

AW456718; Ca4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000805

Encoded Proteins

IDBP-206483

carbonic anhydrase 4

IDBP-265303

carbonic anhydrase 4

IDBP-534167

carbonic anhydrase 4

IDBP-536448

carbonic anhydrase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167434:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:84957786-84966044

Strand

Forward strand

Band

Transcripts

ENSMUST00000103194	ENSMUSP00000099483
ENSMUST00000108076	ENSMUSP00000103711
ENSMUST00000139416
ENSMUST00000138331
ENSMUST00000150596	ENSMUSP00000121381
ENSMUST00000127827	ENSMUSP00000115878

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004089	carbonate dehydratase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006730	one-carbon metabolic process
GO:0006885	regulation of pH
GO:0008152	metabolic process
GO:0015670	carbon dioxide transport
GO:0015701	bicarbonate transport
GO:0042493	response to drug
GO:0048513	organ development
GO:0048545	response to steroid hormone

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0016529	sarcoplasmic reticulum
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane
GO:0031362	anchored component of external side of plasma membrane
GO:0031526	brush border membrane
GO:0042383	sarcolemma
GO:0046658	anchored component of plasma membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome