InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Exo1

Summary

InnateDB Protein

IDBP-206572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Exo1

Protein Name

exonuclease 1

Synonyms

5730442G03Rik; Msa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039376

InnateDB Gene

IDBG-206570 (Exo1)

Protein Structure

UniProt Annotation

Function

5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269PubMed:12629043, ECO:0000269PubMed:14716311}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Colocalizes with PCNA to discrete nuclear foci in S-phase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the spleen and testis. Also expressed in the bone marrow, brain, lung, lymph node and thymus. {ECO:0000269PubMed:10497278}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0008409	5'-3' exonuclease activity
GO:0035312	5'-3' exodeoxyribonuclease activity
GO:0043566	structure-specific DNA binding
GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0046872	metal ion binding
GO:0048256	flap endonuclease activity
GO:0051908	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0000738	DNA catabolic process, exonucleolytic
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0006139	nucleobase-containing compound metabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006310	DNA recombination
GO:0007126	meiotic nuclear division
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0045190	isotype switching
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1349427

InterPro

IPR006085 XPG N-terminal
IPR006086 XPG-I domain
IPR008918 Helix-hairpin-helix motif, class 2
IPR020045 5\'-3\' exonuclease, C-terminal domain
IPR029060 PIN domain-like

PFAM

PF00752
PF00867
PF01367
PF09293

PRINTS

PIRSF

SMART

SM00485
SM00484
SM00279

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QZ11