InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Exo1

Summary

InnateDB Gene

IDBG-206570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Exo1

Gene Name

exonuclease 1

Synonyms

5730442G03Rik; Msa

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039748

Encoded Proteins

IDBP-206572

exonuclease 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174371:
This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a protein with 5\' to 3\' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:175880778-175911396

Strand

Forward strand

Band

Transcripts

ENSMUST00000039725

ENSMUSP00000039376

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0008409	5'-3' exonuclease activity
GO:0035312	5'-3' exodeoxyribonuclease activity
GO:0043566	structure-specific DNA binding
GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0046872	metal ion binding
GO:0048256	flap endonuclease activity
GO:0051908	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0000738	DNA catabolic process, exonucleolytic
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0006139	nucleobase-containing compound metabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006310	DNA recombination
GO:0007126	meiotic nuclear division
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0045190	isotype switching
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000174371

View Gene Order

ENSBTAG00000009396

Not yet available

Pathways

NETPATH

REACTOME

REACT_233397

DNA Repair pathway

REACT_246095

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway

REACT_236124

Mismatch Repair pathway

REACT_240368

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway

KEGG

mmu03430

Mismatch repair pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228145

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway

REACT_228019

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway

REACT_228013

Mismatch Repair pathway

REACT_216

DNA Repair pathway

KEGG

hsa03430

Mismatch repair pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.283046

RefSeq

NM_012012 XM_006496862 XM_006496863

OMIM

CCDS

CCDS15551

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas