Version 5.4
Mus musculus Protein: Ppm1d
Summary
InnateDB Protein IDBP-206619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppm1d
Protein Name protein phosphatase 1D magnesium-dependent, delta isoform
Synonyms AV338790; Wip1;
Species Mus musculus
Ensembl Protein ENSMUSP00000020835
InnateDB Gene IDBG-206617 (Ppm1d)
Protein Structure
UniProt Annotation
Function Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-18' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:10756097}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0009617 response to bacterium
GO:0035970 peptidyl-threonine dephosphorylation
Cellular Component
Protein Structure and Domains
PDB ID MGI:1858214
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like domain
PFAM PF00481
PF07228
PRINTS
PIRSF
SMART SM00331
SM00332
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZ67
PhosphoSite PhosphoSite-Q9QZ67
TrEMBL Q9CW02
UniProt Splice Variant
Entrez Gene 53892
UniGene Mm.415746
RefSeq NP_058606
MGI ID
MGI Symbol Ppm1d
OMIM
CCDS CCDS25194
HPRD
IMGT
EMBL AF200464 AK005658 AK157818 AK171714 BC023492 BX323026
GenPept AAF09251 AAH23492 BAB24170 BAE34209 BAE42627 CAI26197

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca