Version 5.4
| Mus musculus Gene: Ppm1d | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-206617.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Ppm1d | ||||||||||||
| Gene Name | protein phosphatase 1D magnesium-dependent, delta isoform | ||||||||||||
| Synonyms | AV338790; Wip1 | ||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Gene | ENSMUSG00000020525 | ||||||||||||
| Encoded Proteins |
protein phosphatase 1D magnesium-dependent, delta isoform
protein phosphatase 1D magnesium-dependent, delta isoform
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170836:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 11:85311244-85347066 | ||||||||||||
| Strand | Forward strand | ||||||||||||
| Band | C | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME | |||||||||||||
| KEGG |
p53 signaling pathway pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME | |||||||||||||
| KEGG |
p53 signaling pathway pathway
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| INOH | |||||||||||||
| PID NCI |
p53 pathway
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| Cross-References | |||||||||||||
| SwissProt | Q9QZ67 | ||||||||||||
| TrEMBL | Q3TAP1 Q3TZJ9 Q8R1N9 Q9CW02 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 53892 | ||||||||||||
| UniGene | Mm.415746 | ||||||||||||
| RefSeq | NM_016910 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS25194 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| MGI ID | MGI:1858214 | ||||||||||||
| MGI Symbol | Ppm1d | ||||||||||||
| EMBL | AF200464 AK005658 AK157818 AK171714 BC023492 BX323026 | ||||||||||||
| GenPept | AAF09251 AAH23492 BAB24170 BAE34209 BAE42627 CAI26197 | ||||||||||||
| RNA Seq Atlas | 53892 | ||||||||||||