InnateDB Protein
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IDBP-20663.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SH3BP5
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Protein Name
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SH3-domain binding protein 5 (BTK-associated)
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Synonyms
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SAB; SH3BP-5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000373301
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InnateDB Gene
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IDBG-20659 (SH3BP5)
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Protein Structure
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Function |
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269PubMed:10339589, ECO:0000269PubMed:9571151}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:12167088}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate. {ECO:0000269PubMed:9571151}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007940
SH3-binding 5
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PFAM |
PF05276
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O60239
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PhosphoSite |
PhosphoSite-O60239
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TrEMBL |
Q6MZG3
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UniProt Splice Variant |
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Entrez Gene |
9467
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UniGene |
Hs.257761
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RefSeq |
NP_004835
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HUGO |
HGNC:10827
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OMIM |
605612
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CCDS |
CCDS2625
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HPRD |
12030
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IMGT |
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EMBL |
AB005047
AC087590
AK090524
AK313167
AL117422
BC010123
BX641159
CH471055
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GenPept |
AAH10123
BAA25922
BAG35985
BAG52178
CAE46071
CAI46220
EAW64225
EAW64226
EAW64227
EAW64228
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