InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itpa

Summary

InnateDB Protein

IDBP-206662.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itpa

Protein Name

inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

Synonyms

2010016I08Rik; AU020102; Itp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099482

InnateDB Gene

IDBG-206660 (Itpa)

Protein Structure

UniProt Annotation

Function

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255HAMAP-Rule:MF_03148, ECO:0000269PubMed:17090528, ECO:0000269PubMed:20081199, ECO:0000269PubMed:20601097}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03148}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0016787	hydrolase activity
GO:0035870	dITP diphosphatase activity
GO:0036220	ITP diphosphatase activity
GO:0036222	XTP diphosphatase activity
GO:0046872	metal ion binding
GO:0047429	nucleoside-triphosphate diphosphatase activity