InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itpa

Summary

InnateDB Gene

IDBG-206660.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itpa

Gene Name

inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

Synonyms

2010016I08Rik; AU020102; Itp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074797

Encoded Proteins

IDBP-206662

inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125877:
This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:130667610-130681614

Strand

Forward strand

Band

Transcripts

ENSMUST00000103193	ENSMUSP00000099482
ENSMUST00000156382
ENSMUST00000133328
ENSMUST00000138963
ENSMUST00000126714

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0016787	hydrolase activity
GO:0035870	dITP diphosphatase activity
GO:0036220	ITP diphosphatase activity
GO:0036222	XTP diphosphatase activity
GO:0046872	metal ion binding
GO:0047429	nucleoside-triphosphate diphosphatase activity

Biological Process

GO:0006193	ITP catabolic process
GO:0009204	deoxyribonucleoside triphosphate catabolic process
GO:0051276	chromosome organization

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000125877

View Gene Order

ENSBTAG00000013776

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_245662

Metabolism of nucleotides pathway

KEGG

mmu00240

Pyrimidine metabolism pathway

mmu00230

Purine metabolism pathway

mmu00983

Drug metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

REACT_210940

Metabolism of nucleotides pathway

REACT_219139

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00230

Purine metabolism pathway

hsa00983

Drug metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.21399 Mm.403243 Mm.404207 Mm.404589 Mm.405463 Mm.426272 Mm.437940 Mm.471029

RefSeq

NM_025922

OMIM

CCDS

CCDS16748

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas