InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc4a11

Summary

InnateDB Protein

IDBP-206680.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc4a11

Protein Name

solute carrier family 4, sodium bicarbonate transporter-like, member 11

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096963

InnateDB Gene

IDBG-206678 (Slc4a11)

Protein Structure

UniProt Annotation

Function

Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. {ECO:0000269PubMed:20185830}.

Subcellular Localization

Cell membrane. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the endothelial cells of the cornea. In the inner ear, is located in fibrocytes underlying the stria vascularis. In the kidney, is expressed in the thin descending limb of Henle loop. {ECO:0000269PubMed:20185830}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0008509	anion transmembrane transporter activity
GO:0015293	symporter activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006810	transport
GO:0006820	anion transport
GO:0042044	fluid transport
GO:0050801	ion homeostasis
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2138987

InterPro

IPR002178 PTS EIIA type-2 domain
IPR003020 Bicarbonate transporter, eukaryotic
IPR011531 Bicarbonate transporter, C-terminal
IPR013769 Band 3 cytoplasmic domain
IPR016152 Phosphotransferase/anion transporter

PFAM

PF00359
PF00955
PF07565

PRINTS

PR01231

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2AJN7