InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atrn

Summary

InnateDB Protein

IDBP-206750.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atrn

Protein Name

attractin

Synonyms

AW558010; mahogany; mg; Mgca; mKIAA0548;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028781

InnateDB Gene

IDBG-206748 (Atrn)

Protein Structure

UniProt Annotation

Function

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity). May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006954	inflammatory response
GO:0006979	response to oxidative stress
GO:0007275	multicellular organismal development
GO:0021549	cerebellum development
GO:0040014	regulation of multicellular organism growth
GO:0042552	myelination
GO:0043473	pigmentation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1341628

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000859 CUB domain
IPR001304 C-type lectin
IPR002049 EGF-like, laminin
IPR002165 Plexin
IPR006652 Kelch repeat type 1
IPR016187 C-type lectin fold
IPR016201 Plexin-like fold

PFAM

PF00008
PF00431
PF00059
PF00053
PF01437
PF01344

PRINTS

PIRSF

SMART

SM00181
SM00042
SM00034
SM00180
SM00612
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WU60