InnateDB Protein
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IDBP-206788.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gfra4
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Protein Name
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glial cell line derived neurotrophic factor family receptor alpha 4
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Synonyms
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AW060733; G630015H18Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000068357
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InnateDB Gene
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IDBG-206782 (Gfra4)
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Protein Structure
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Function |
Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
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Subcellular Localization |
Isoform a1: Cell membrane; Lipid-anchor, GPI-anchor.Isoform b1: Cell membrane; Lipid-anchor, GPI-anchor.Isoform a3: Secreted {ECO:0000305}.Isoform b3: Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in many tissues including adrenal medulla, brain neurons, with highest levels in the cerebral cortex and hippocampus. Moderate levels found in the gut circular muscle and myenteric ganglia as well as in other peripheral ganglia, including the sensory dorsal root and trigeminal as well as superior cervical and sympathetic chain ganglia. Isoform a1, isoform a2, isoform b1 and isoform b2 are exclusively found in the thyroid, parthyroid and pituitary glands.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0015026
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coreceptor activity
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GO:0016167
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glial cell-derived neurotrophic factor receptor activity
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Biological Process |
GO:0007169
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transmembrane receptor protein tyrosine kinase signaling pathway
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GO:0030279
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negative regulation of ossification
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GO:0035860
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glial cell-derived neurotrophic factor receptor signaling pathway
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Cellular Component |
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PDB ID |
MGI:1341873
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InterPro |
IPR003438
Glial cell line-derived neurotrophic factor receptor
IPR016017
GDNF/GAS1
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PFAM |
PF02351
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PRINTS |
PR01316
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PIRSF |
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SMART |
SM00907
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JJT2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14588
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UniGene |
Mm.198399
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RefSeq |
NP_001257930
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MGI ID |
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MGI Symbol |
Gfra4
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OMIM |
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CCDS |
CCDS59638
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HPRD |
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IMGT |
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EMBL |
AJ276514
AJ276515
AJ276516
AJ276870
AJ276871
AJ276872
AL833771
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GenPept |
CAB89687
CAB89688
CAB89689
CAB89690
CAB89691
CAB89692
CAM18037
CAM18039
CAM18040
CAM18042
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