Mus musculus Gene: Gfra4
Summary
InnateDB Gene IDBG-206782.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gfra4
Gene Name glial cell line derived neurotrophic factor family receptor alpha 4
Synonyms AW060733; G630015H18Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000027316
Encoded Proteins
glial cell line derived neurotrophic factor family receptor alpha 4
glial cell line derived neurotrophic factor family receptor alpha 4
glial cell line derived neurotrophic factor family receptor alpha 4
glial cell line derived neurotrophic factor family receptor alpha 4
glial cell line derived neurotrophic factor family receptor alpha 4
glial cell line derived neurotrophic factor family receptor alpha 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125861:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:131039632-131043088
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000028787 ENSMUSP00000028787
ENSMUST00000066958 ENSMUSP00000068357
ENSMUST00000110240 ENSMUSP00000105869
ENSMUST00000110239 ENSMUSP00000105868
ENSMUST00000110235 ENSMUSP00000105864
ENSMUST00000110234 ENSMUSP00000105863
ENSMUST00000156509
ENSMUST00000136569
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015026 coreceptor activity
GO:0016167 glial cell-derived neurotrophic factor receptor activity
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0030279 negative regulation of ossification
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
NCAM1 interactions pathway
NCAM signaling for neurite out-growth pathway
Developmental Biology pathway
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.198399
RefSeq NM_001136063 NM_001271001 NM_001271002 NM_020014
OMIM
CCDS CCDS16752 CCDS50715 CCDS59637 CCDS59638
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas