InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rps6kb1

Summary

InnateDB Protein

IDBP-206899.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Rps6kb1

Protein Name

ribosomal protein S6 kinase, polypeptide 1

Synonyms

2610318I15Rik; 4732464A07Rik; 70kDa; AA959758; AI256796; AI314060; p70/85s6k; p70s6k; S6K1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053188

InnateDB Gene

IDBG-206895 (Rps6kb1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004711	ribosomal protein S6 kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042277	peptide binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0003009	skeletal muscle contraction
GO:0006468	protein phosphorylation
GO:0007281	germ cell development
GO:0007568	aging
GO:0007584	response to nutrient
GO:0007616	long-term memory
GO:0009408	response to heat
GO:0009611	response to wounding
GO:0009612	response to mechanical stimulus
GO:0009636	response to toxic substance
GO:0009749	response to glucose
GO:0014732	skeletal muscle atrophy
GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016477	cell migration
GO:0031929	TOR signaling
GO:0032496	response to lipopolysaccharide
GO:0032868	response to insulin
GO:0032870	cellular response to hormone stimulus
GO:0033574	response to testosterone
GO:0033762	response to glucagon
GO:0034612	response to tumor necrosis factor
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043201	response to leucine
GO:0043491	protein kinase B signaling
GO:0045471	response to ethanol
GO:0045931	positive regulation of mitotic cell cycle
GO:0045948	positive regulation of translational initiation
GO:0046324	regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0048633	positive regulation of skeletal muscle tissue growth
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051384	response to glucocorticoid
GO:0071363	cellular response to growth factor stimulus
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0009986	cell surface
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1270849

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt