InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trp73

Summary

InnateDB Protein

IDBP-206906.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trp73

Protein Name

transformation related protein 73

Synonyms

p73; TAp73; Tp73;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095368

InnateDB Gene

IDBG-206900 (Trp73)

Protein Structure

UniProt Annotation

Function

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. {ECO:0000250UniProtKB:O15350, ECO:0000269PubMed:10232589, ECO:0000269PubMed:11932750}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15113856}. Cytoplasm {ECO:0000250}. Note=Accumulates in the nucleus in response to DNA damage. {ECO:0000269PubMed:15113856}.

Disease Associations

Tissue Specificity

Found in striatal neurons of mutant huntingtin (htt) transgenic mice (at protein level). Isoform 1 is expressed in the nasal epithelium, the vomeronasal organ, the hippocampus and the hypothalamus. {ECO:0000269PubMed:10716451, ECO:0000269PubMed:16461361}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	102 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000187	activation of MAPK activity
GO:0001822	kidney development
GO:0001836	release of cytochrome c from mitochondria
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006954	inflammatory response
GO:0006974	cellular response to DNA damage stimulus
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050	cell cycle arrest
GO:0009791	post-embryonic development
GO:0010165	response to X-ray
GO:0010243	response to organonitrogen compound
GO:0010332	response to gamma radiation
GO:0021766	hippocampus development
GO:0030900	forebrain development
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0033326	cerebrospinal fluid secretion
GO:0034644	cellular response to UV
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065	positive regulation of apoptotic process
GO:0043508	negative regulation of JUN kinase activity
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045665	negative regulation of neuron differentiation
GO:0045793	positive regulation of cell size
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048546	digestive tract morphogenesis
GO:0048666	neuron development
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0051262	protein tetramerization
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1336991

InterPro

IPR002117 p53 tumour suppressor family
IPR008967 p53-like transcription factor, DNA-binding
IPR010991 p53, tetramerisation domain
IPR011510 Sterile alpha motif, type 2
IPR011615 p53, DNA-binding domain
IPR013761 Sterile alpha motif/pointed domain

PFAM

PF07710
PF07647
PF00870

PRINTS

PR00386

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JJP2