InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dkk3

Summary

InnateDB Protein

IDBP-206915.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dkk3

Protein Name

dickkopf homolog 3 (Xenopus laevis)

Synonyms

AW061014; C87148;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033036

InnateDB Gene

IDBG-206913 (Dkk3)

Protein Structure

UniProt Annotation

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest expression in brain, eye and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007275	multicellular organismal development
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030325	adrenal gland development
GO:0032348	negative regulation of aldosterone biosynthetic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000065	negative regulation of cortisol biosynthetic process