Version 5.4
Mus musculus Gene: Dkk3
Summary
InnateDB Gene IDBG-206913.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dkk3
Gene Name dickkopf homolog 3 (Xenopus laevis)
Synonyms AW061014; C87148
Species Mus musculus
Ensembl Gene ENSMUSG00000030772
Encoded Proteins
IDBP-206915
dickkopf homolog 3 (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000050165:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:112116019-112159057
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000033036 ENSMUSP00000033036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030325 adrenal gland development
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000065 negative regulation of cortisol biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000050165
View Gene Order
ENSBTAG00000004275
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Cross-References
SwissProt Q9QUN9
TrEMBL
UniProt Splice Variant
Entrez Gene 50781
UniGene Mm.472196 Mm.55143
RefSeq NM_015814 XM_006508013
OMIM
CCDS CCDS21752
HPRD
IMGT
MGI ID MGI:1354952
MGI Symbol Dkk3
EMBL AF177400 AJ243964 AK004853 BC046304 BC050934
GenPept AAF02680 AAH46304 AAH50934 BAB23617 CAB60111
RNA Seq Atlas 50781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca