InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cenpb

Summary

InnateDB Protein

IDBP-207003.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cenpb

Protein Name

centromere protein B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086938

InnateDB Gene

IDBG-206999 (Cenpb)

Protein Structure

UniProt Annotation

Function

Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Chromosome, centromere.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding

Biological Process

GO:0006355

regulation of transcription, DNA-templated

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:88376

InterPro

IPR004875 DDE superfamily endonuclease, CENP-B-like
IPR006600 HTH CenpB-type DNA-binding domain
IPR007889 DNA binding HTH domain, Psq-type
IPR009057 Homeodomain-like
IPR015115 Centromere protein CENP-B, dimerisation domain

PFAM

PF03184
PF03221
PF04218
PF05225
PF09026

PRINTS

PIRSF

SMART

SM00674

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P27790