Version 5.4
Mus musculus Gene: Cenpb
Summary
InnateDB Gene IDBG-206999.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cenpb
Gene Name centromere protein B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000068267
Encoded Proteins
IDBP-207003
centromere protein B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125817:
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:131175182-131180067
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000089510 ENSMUSP00000086938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125817
View Gene Order
ENSBTAG00000045784
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt P27790
TrEMBL Q3TY85
UniProt Splice Variant
Entrez Gene 12616
UniGene Mm.440169
RefSeq NM_007682
OMIM
CCDS CCDS16757
HPRD
IMGT
MGI ID MGI:88376
MGI Symbol Cenpb
EMBL AK158811 AL831736 BC053333 BC071269 BC075733 X55038
GenPept AAH53333 AAH71269 AAH75733 BAE34678 CAA38878
RNA Seq Atlas 12616

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca