Mus musculus Protein: Cdc42bpa | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Protein | IDBP-207039.6 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | Cdc42bpa | ||||||||||||||||
Protein Name | CDC42 binding protein kinase alpha | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Mus musculus | ||||||||||||||||
Ensembl Protein | ENSMUSP00000095059 | ||||||||||||||||
InnateDB Gene | IDBG-207029 (Cdc42bpa) | ||||||||||||||||
Protein Structure | |||||||||||||||||
UniProt Annotation | |||||||||||||||||
Function | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LRP35A, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake (By similarity). {ECO:0000250}. | ||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}. | ||||||||||||||||
Disease Associations | |||||||||||||||||
Tissue Specificity | |||||||||||||||||
Comments | |||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||
PDB ID | MGI:2441841 | ||||||||||||||||
InterPro |
IPR000095
CRIB domain IPR000719 Protein kinase domain IPR000961 AGC-kinase, C-terminal IPR001180 Citron-like IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001849 Pleckstrin homology domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR014930 Myotonic dystrophy protein kinase, coiled coil IPR017892 Protein kinase, C-terminal IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00786
PF00069 PF00780 PF07714 PF00169 PF00130 PF08826 PF00433 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||
SMART |
SM00285
SM00133 SM00036 SM00233 SM00109 SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||
Post-translational Modifications | |||||||||||||||||
Modification | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | Q3UU96 | ||||||||||||||||
PhosphoSite | PhosphoSite-Q3UU96 | ||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 226751 | ||||||||||||||||
UniGene | Mm.259655 | ||||||||||||||||
RefSeq | XP_006496873 | ||||||||||||||||
MGI ID | |||||||||||||||||
MGI Symbol | Cdc42bpa | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | AC125380 AC132436 AF492452 AK129148 AK138649 BC096679 BC158095 | ||||||||||||||||
GenPept | AAH96679 AAI58096 AAM10976 BAC97958 BAE23731 | ||||||||||||||||