InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdc42bpa

Summary

InnateDB Gene

IDBG-207029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc42bpa

Gene Name

CDC42 binding protein kinase alpha

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026490

Encoded Proteins

IDBP-207031

CDC42 binding protein kinase alpha

IDBP-207035

CDC42 binding protein kinase alpha

IDBP-207039

CDC42 binding protein kinase alpha

IDBP-258803

CDC42 binding protein kinase alpha

IDBP-537581

CDC42 binding protein kinase alpha

IDBP-533379

CDC42 binding protein kinase alpha

IDBP-539061

CDC42 binding protein kinase alpha

IDBP-535662

CDC42 binding protein kinase alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143776:
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:179960472-180165603

Strand

Forward strand

Band

Transcripts

ENSMUST00000097453	ENSMUSP00000095062
ENSMUST00000076687	ENSMUSP00000075980
ENSMUST00000097450	ENSMUSP00000095059
ENSMUST00000111117	ENSMUSP00000106746
ENSMUST00000134959
ENSMUST00000143350
ENSMUST00000132894
ENSMUST00000139002
ENSMUST00000133890	ENSMUSP00000116337
ENSMUST00000152582
ENSMUST00000143176	ENSMUSP00000115261
ENSMUST00000135056	ENSMUSP00000114333
ENSMUST00000145181	ENSMUSP00000118039
ENSMUST00000143161
ENSMUST00000145274
ENSMUST00000129754

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006468	protein phosphorylation
GO:0007097	nuclear migration
GO:0016477	cell migration
GO:0031032	actomyosin structure organization
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005737	cytoplasm
GO:0042641	actomyosin
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000143776

View Gene Order

ENSBTAG00000022777

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

cdc42_pathway

CDC42 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.259655

RefSeq

NM_001033285 XM_006496801 XM_006496802 XM_006496803 XM_006496804 XM_006496805 XM_006496806 XM_006496807 XM_006496809 XM_006496811 XM_006496814

OMIM

CCDS

CCDS48466

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas