InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psen2

Summary

InnateDB Protein

IDBP-207111.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psen2

Protein Name

presenilin 2

Synonyms

Ad4h; ALG-3; Alg3; PS-2; PS2; Psnl2; STM2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010753

InnateDB Gene

IDBG-207109 (Psen2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0001708	cell fate specification
GO:0001756	somitogenesis
GO:0001933	negative regulation of protein phosphorylation
GO:0001942	hair follicle development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002286	T cell activation involved in immune response
GO:0002573	myeloid leukocyte differentiation
GO:0006509	membrane protein ectodomain proteolysis
GO:0006816	calcium ion transport
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007611	learning or memory
GO:0007613	memory
GO:0015031	protein transport
GO:0016485	protein processing
GO:0021904	dorsal/ventral neural tube patterning
GO:0030326	embryonic limb morphogenesis
GO:0030900	forebrain development
GO:0031333	negative regulation of protein complex assembly
GO:0032091	negative regulation of protein binding
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0035556	intracellular signal transduction
GO:0040011	locomotion
GO:0042640	anagen
GO:0042987	amyloid precursor protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043393	regulation of protein binding
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048167	regulation of synaptic plasticity
GO:0048286	lung alveolus development
GO:0048538	thymus development
GO:0048854	brain morphogenesis
GO:0050435	beta-amyloid metabolic process
GO:0050820	positive regulation of coagulation
GO:0050852	T cell receptor signaling pathway
GO:0051604	protein maturation
GO:0060048	cardiac muscle contraction
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005637	nuclear inner membrane
GO:0005743	mitochondrial inner membrane
GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030018	Z disc
GO:0030424	axon
GO:0030426	growth cone
GO:0031594	neuromuscular junction
GO:0035253	ciliary rootlet
GO:0036064	ciliary basal body
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm