InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Card11

Summary

InnateDB Protein

IDBP-207120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Card11

Protein Name

caspase recruitment domain family, member 11

Synonyms

0610008L17Rik; 2410011D02Rik; BIMP3; CARMA1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082941

InnateDB Gene

IDBG-207118 (Card11)

Protein Structure

UniProt Annotation

Function

Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050700	CARD domain binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0007165	signal transduction
GO:0030890	positive regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045061	thymic T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045577	regulation of B cell differentiation
GO:0045580	regulation of T cell differentiation
GO:0050776	regulation of immune response
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0001772	immunological synapse
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0042101	T cell receptor complex
GO:0045121	membrane raft