InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Card11

Summary

InnateDB Gene

IDBG-207118.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Card11

Gene Name

caspase recruitment domain family, member 11

Synonyms

0610008L17Rik; 2410011D02Rik; BIMP3; CARMA1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036526

Encoded Proteins

IDBP-207120

caspase recruitment domain family, member 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198286:
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:140872999-141000596

Strand

Reverse strand

Band

Transcripts

ENSMUST00000085786

ENSMUSP00000082941

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050700	CARD domain binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0007165	signal transduction
GO:0030890	positive regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045061	thymic T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045577	regulation of B cell differentiation
GO:0045580	regulation of T cell differentiation
GO:0050776	regulation of immune response
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0001772	immunological synapse
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0042101	T cell receptor complex
GO:0045121	membrane raft