InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim37

Summary

InnateDB Protein

IDBP-207242.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim37

Protein Name

tripartite motif-containing 37

Synonyms

1110032A10Rik; 2810004E07Rik; AI848587; AU043018; mKIAA0898; MUL; TEF3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049057

InnateDB Gene

IDBG-207240 (Trim37)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Peroxisome {ECO:0000250}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0046600	negative regulation of centriole replication
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:0070842	aggresome assembly