InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim37

Summary

InnateDB Gene

IDBG-207240.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim37

Gene Name

tripartite motif-containing 37

Synonyms

1110032A10Rik; 2810004E07Rik; AI848587; AU043018; mKIAA0898; MUL; TEF3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018548

Encoded Proteins

IDBP-207242

tripartite motif-containing 37

IDBP-541018

tripartite motif-containing 37

IDBP-539163

tripartite motif-containing 37

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] TRIM37 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:87127077-87220683

Strand

Forward strand

Band

Transcripts

ENSMUST00000041282	ENSMUSP00000049057
ENSMUST00000139532	ENSMUSP00000119269
ENSMUST00000152637
ENSMUST00000154138	ENSMUSP00000118260

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0046600	negative regulation of centriole replication
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:0070842	aggresome assembly

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0016235	aggresome
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000108395

View Gene Order

ENSBTAG00000021677

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.17436

RefSeq

NM_197987 XM_006534073 XM_006536462

OMIM

CCDS

CCDS25210

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas