InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mixl1

Summary

InnateDB Protein

IDBP-207258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mixl1

Protein Name

Mix1 homeobox-like 1 (Xenopus laevis)

Synonyms

Mm1; Mml;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027778

InnateDB Gene

IDBG-207256 (Mixl1)

Protein Structure

UniProt Annotation

Function

Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression. {ECO:0000269PubMed:12117810, ECO:0000269PubMed:15673572, ECO:0000269PubMed:16403910, ECO:0000269PubMed:17060613, ECO:0000269PubMed:17151016, ECO:0000269PubMed:17446562}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:12619131}.

Disease Associations

Tissue Specificity

Expressed in the primitive streak of the gastrulating embryo, and marks cells destined to form mesoderm and endoderm. Present in differentiating embryonic stem cells (at protein level). {ECO:0000269PubMed:12619131, ECO:0000269PubMed:16433620}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001706	endoderm formation
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007369	gastrulation
GO:0007492	endoderm development
GO:0007507	heart development
GO:0030097	hemopoiesis
GO:0035987	endodermal cell differentiation
GO:0042074	cell migration involved in gastrulation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:1901533	negative regulation of hematopoietic progenitor cell differentiation
GO:2000382	positive regulation of mesoderm development