InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Calca

Summary

InnateDB Protein

IDBP-207272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Calca

Protein Name

calcitonin/calcitonin-related polypeptide, alpha

Synonyms

CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct; Ctn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032906

InnateDB Gene

IDBG-207270 (Calca)

Protein Structure

UniProt Annotation

Function

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult. {ECO:0000269PubMed:18544925}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0031716	calcitonin receptor binding

Biological Process

GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
GO:0001984	vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
GO:0002027	regulation of heart rate
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007218	neuropeptide signaling pathway
GO:0007631	feeding behavior
GO:0009408	response to heat
GO:0030279	negative regulation of ossification
GO:0031645	negative regulation of neurological system process
GO:0045776	negative regulation of blood pressure
GO:0045778	positive regulation of ossification
GO:0045986	negative regulation of smooth muscle contraction
GO:0048240	sperm capacitation
GO:0048265	response to pain
GO:0050965	detection of temperature stimulus involved in sensory perception of pain

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton

Protein Structure and Domains

PDB ID

MGI:2151253

InterPro

IPR000443 Pro-islet amyloid polypeptide
IPR001693 Calcitonin peptide-like
IPR015476 Calcitonin gene-related peptide
IPR021116 Procalcitonin/adrenomedullin

PFAM

PF00214

PRINTS

PR00818
PR00817

PIRSF

SMART

SM00113

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt