InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Calca

Summary

InnateDB Gene

IDBG-207270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Calca

Gene Name

calcitonin/calcitonin-related polypeptide, alpha

Synonyms

CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct; Ctn

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030669

Encoded Proteins

IDBP-207272

calcitonin/calcitonin-related polypeptide, alpha

IDBP-207274

calcitonin/calcitonin-related polypeptide, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20141542

[Homo sapiens] CALCA can be produced by immune cells such as monocytes/macrophages following inflammatory stimulation and has a positive or negative reciprocal effect on the production of other pro- and anti-inflammatory mediators, playing both facilitating and suppressing roles in immune and inflammatory responses as shown in mice.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110680:
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:114631480-114636357

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032906	ENSMUSP00000032906
ENSMUST00000032907	ENSMUSP00000032907

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0031716	calcitonin receptor binding
GO:0042802	identical protein binding

Biological Process

GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
GO:0001984	vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
GO:0002027	regulation of heart rate
GO:0002548	monocyte chemotaxis
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007566	embryo implantation
GO:0007568	aging
GO:0007631	feeding behavior
GO:0008016	regulation of heart contraction
GO:0009408	response to heat
GO:0030279	negative regulation of ossification
GO:0031645	negative regulation of neurological system process
GO:0032147	activation of protein kinase activity
GO:0042311	vasodilation
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045776	negative regulation of blood pressure
GO:0045778	positive regulation of ossification
GO:0045779	negative regulation of bone resorption
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045986	negative regulation of smooth muscle contraction
GO:0048240	sperm capacitation
GO:0048265	response to pain
GO:0050727	regulation of inflammatory response
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0071356	cellular response to tumor necrosis factor
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton