InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Calca

Summary

InnateDB Protein

IDBP-207274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Calca

Protein Name

calcitonin/calcitonin-related polypeptide, alpha

Synonyms

CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct; Ctn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032907

InnateDB Gene

IDBG-207270 (Calca)

Protein Structure

UniProt Annotation

Function

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0031716	calcitonin receptor binding
GO:0042802	identical protein binding

Biological Process

GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
GO:0001984	vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
GO:0002027	regulation of heart rate
GO:0002548	monocyte chemotaxis
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007566	embryo implantation
GO:0007568	aging
GO:0007631	feeding behavior
GO:0008016	regulation of heart contraction
GO:0009408	response to heat
GO:0030279	negative regulation of ossification
GO:0031645	negative regulation of neurological system process
GO:0032147	activation of protein kinase activity
GO:0042311	vasodilation
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045776	negative regulation of blood pressure
GO:0045778	positive regulation of ossification
GO:0045779	negative regulation of bone resorption
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045986	negative regulation of smooth muscle contraction
GO:0048240	sperm capacitation
GO:0048265	response to pain
GO:0050727	regulation of inflammatory response
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0071356	cellular response to tumor necrosis factor
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton