InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wipi2

Summary

InnateDB Protein

IDBP-207362.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wipi2

Protein Name

WD repeat domain, phosphoinositide interacting 2

Synonyms

1110018O08Rik; 2510001I10Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045201

InnateDB Gene

IDBG-207360 (Wipi2)

Protein Structure

UniProt Annotation

Function

Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. {ECO:0000250}.

Subcellular Localization

Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Enriched at preautophagosomal structure membranes in response to ptdIns3P. Dissociates from mature phagosome membranes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0000045

autophagic vacuole assembly

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005829	cytosol
GO:0034045	pre-autophagosomal structure membrane
GO:0043234	protein complex