Version 5.4
Mus musculus Gene: Wipi2
Summary
InnateDB Gene IDBG-207360.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wipi2
Gene Name WD repeat domain, phosphoinositide interacting 2
Synonyms 1110018O08Rik; 2510001I10Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000029578
Encoded Proteins
IDBP-207362
WD repeat domain, phosphoinositide interacting 2
IDBP-259521
WD repeat domain, phosphoinositide interacting 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157954:
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:142629542-142670588
Strand Forward strand
Band G2
Transcripts
ENSMUST00000036872 ENSMUSP00000045201
ENSMUST00000110778 ENSMUSP00000106405
ENSMUST00000153936
ENSMUST00000143980
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0000045 autophagic vacuole assembly
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005829 cytosol
GO:0034045 pre-autophagosomal structure membrane
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000157954
View Gene Order
ENSBTAG00000012049
Not yet available
Cross-References
SwissProt Q80W47
TrEMBL
UniProt Splice Variant
Entrez Gene 74781
UniGene Mm.29432 Mm.397801 Mm.408570 Mm.470183
RefSeq NM_178398 XM_006504751 XM_006504752
OMIM
CCDS CCDS19828
HPRD
IMGT
MGI ID MGI:1923831
MGI Symbol Wipi2
EMBL AK155113 AK169051 AK172030 BC044894
GenPept AAH44894 BAE33057 BAE40839 BAE42786
RNA Seq Atlas 74781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca