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InnateDB Protein
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IDBP-207383.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc29a4
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Protein Name
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solute carrier family 29 (nucleoside transporters), member 4
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000059896
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InnateDB Gene
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IDBG-207381 (Slc29a4)
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Protein Structure
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| Function |
Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorptprev reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (By similarity). {ECO:0000250, ECO:0000269PubMed:16873718}.
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| Subcellular Localization |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells (By similarity). {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Expressed in heart. {ECO:0000269PubMed:16873718}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
| Accession |
GO Term |
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GO:0005337
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nucleoside transmembrane transporter activity
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GO:0008504
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monoamine transmembrane transporter activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:2385330
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| InterPro |
IPR002259
Equilibrative nucleoside transporter
IPR016196
Major facilitator superfamily domain, general substrate transporter
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| PFAM |
PF01733
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| PRINTS |
PR01130
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| PIRSF |
PIRSF016379
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q8R139
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| PhosphoSite |
PhosphoSite-Q8R139
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
243328
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| UniGene |
Mm.125942
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| RefSeq |
NP_666369
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| MGI ID |
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| MGI Symbol |
Slc29a4
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| OMIM |
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| CCDS |
CCDS39364
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| HPRD |
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| IMGT |
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| EMBL |
BC025599
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| GenPept |
AAH25599
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Version 5.4