Version 5.4
Mus musculus Protein: Sept4
Summary
InnateDB Protein IDBP-207404.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sept4
Protein Name septin 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000018544
InnateDB Gene IDBG-207394 (Sept4)
Protein Structure
UniProt Annotation
Function Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). {ECO:0000250, ECO:0000305}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12581152, ECO:0000269PubMed:17546647}. Cytoplasm, cytoskeleton {ECO:0000250}.Isoform 4: Mitochondrion. Note=In retinoic acid-treated P19 cells, isoform 4 is found first in the mitochondria and at later times, as neuronal differentiation proceeds, in the cytosol.
Disease Associations
Tissue Specificity Expressed in the brain. Abundant in areas of high cell density, particularly in the stria terminalis. Isoform 4 is predominantly expressed in embryonic mouse brain and dorsal root ganglion neurons. {ECO:0000269PubMed:12581152}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0007049 cell cycle
GO:0007286 spermatid development
GO:0007420 brain development
GO:0030382 sperm mitochondrion organization
GO:0031398 positive regulation of protein ubiquitination
GO:0043065 positive regulation of apoptotic process
GO:0048240 sperm capacitation
GO:0051301 cell division
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0031105 septin complex
GO:0031514 motile cilium
GO:0036126 sperm flagellum
GO:0042995 cell projection
GO:0097227 sperm annulus
Protein Structure and Domains
PDB ID MGI:1270156
InterPro IPR000038 Cell division protein GTP binding
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00735
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28661
PhosphoSite PhosphoSite-P28661
TrEMBL
UniProt Splice Variant
Entrez Gene 18952
UniGene
RefSeq NP_035259
MGI ID
MGI Symbol Sept4
OMIM
CCDS CCDS25213
HPRD
IMGT
EMBL AB078010 AK133933 AK135143 AK137299 AL596086 BC055101 CH466556 CU406988 X61452
GenPept AAH55101 BAC55241 BAE21934 BAE22437 BAE23298 CAA43692 CAI35128 CAI35129 CAI35132 CAI35133 CAI35134 CAQ52271 CAQ52272 CAQ52274 CAQ52275 CAQ52276 EDL15822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca