InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sept4

Summary

InnateDB Gene

IDBG-207394.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sept4

Gene Name

septin 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020486

Encoded Proteins

IDBP-207404

septin 4

IDBP-207406

septin 4

IDBP-265555

septin 4

IDBP-265557

septin 4

IDBP-265559

septin 4

IDBP-400100

septin 4

IDBP-533206

septin 4

IDBP-532732

septin 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108387:
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:87568903-87590539

Strand

Forward strand

Band

Transcripts

ENSMUST00000018544	ENSMUSP00000018544
ENSMUST00000063156	ENSMUSP00000060127
ENSMUST00000107962	ENSMUSP00000103596
ENSMUST00000107961	ENSMUSP00000103595
ENSMUST00000107960	ENSMUSP00000103594
ENSMUST00000122067	ENSMUSP00000112960
ENSMUST00000122945	ENSMUSP00000115682
ENSMUST00000140398
ENSMUST00000132723
ENSMUST00000123081
ENSMUST00000133638
ENSMUST00000135175
ENSMUST00000136229
ENSMUST00000134923
ENSMUST00000133202	ENSMUSP00000115790
ENSMUST00000148216
ENSMUST00000127414
ENSMUST00000143950

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0007049	cell cycle
GO:0007286	spermatid development
GO:0007420	brain development
GO:0030382	sperm mitochondrion organization
GO:0031398	positive regulation of protein ubiquitination
GO:0043065	positive regulation of apoptotic process
GO:0048240	sperm capacitation
GO:0051301	cell division
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0031105	septin complex
GO:0031514	motile cilium
GO:0036126	sperm flagellum
GO:0042995	cell projection
GO:0097227	sperm annulus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000108387

View Gene Order

ENSBTAG00000015368

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001284392 NM_001284394 NM_001284398 NM_011129 XM_006532498 XM_006532499 XM_006532500 XM_006536445 XM_006536446 XM_006536447

OMIM

CCDS

CCDS25213 CCDS70275 CCDS70276 CCDS70277

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas