InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf216

Summary

InnateDB Protein

IDBP-207537.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf216

Protein Name

ring finger protein 216

Synonyms

2810055G22Rik; AI647468; AU019462; C86502; F830018F18Rik; TRIAD3; Ubce7ip1; UIP83;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052563

InnateDB Gene

IDBG-207535 (Rnf216)

Protein Structure

UniProt Annotation

Function

Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Promotes TNF and RIP mediated apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006915	apoptotic process
GO:0032648	regulation of interferon-beta production
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050691	regulation of defense response to virus by host
GO:0070936	protein K48-linked ubiquitination