Version 5.4
Mus musculus Gene: Rnf216
Summary
InnateDB Gene IDBG-207535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf216
Gene Name ring finger protein 216
Synonyms 2810055G22Rik; AI647468; AU019462; C86502; F830018F18Rik; TRIAD3; Ubce7ip1; UIP83
Species Mus musculus
Ensembl Gene ENSMUSG00000045078
Encoded Proteins
IDBP-207537
ring finger protein 216
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011275:
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:142990893-143113020
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000053498 ENSMUSP00000052563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0006915 apoptotic process
GO:0032648 regulation of interferon-beta production
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050691 regulation of defense response to virus by host
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000011275
View Gene Order
ENSBTAG00000017175
Not yet available
Cross-References
SwissProt P58283
TrEMBL
UniProt Splice Variant
Entrez Gene 108086
UniGene Mm.381440 Mm.399504 Mm.488397
RefSeq NM_080561 NM_207110 XM_006504644 XM_006504645 XM_006504647 XM_006504648
OMIM
CCDS CCDS57400
HPRD
IMGT
MGI ID MGI:1344349
MGI Symbol Rnf216
EMBL AF361000 AK089775 AK147861 AK149741 AK154368 AY572785 AY572786 BC065066 BC079540
GenPept AAH65066 AAH79540 AAK51470 AAS78930 AAS78931 BAC40959 BAE28184 BAE29055 BAE32540
RNA Seq Atlas 108086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca