InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARIH1

Summary

InnateDB Protein

IDBP-20754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARIH1

Protein Name

ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)

Synonyms

ARI; HARI; HHARI; UBCH7BP;

Species

Homo sapiens

Ensembl Protein

ENSP00000369217

InnateDB Gene

IDBG-20750 (ARIH1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. {ECO:0000269PubMed:14623119, ECO:0000269PubMed:15236971, ECO:0000269PubMed:17289916, ECO:0000269PubMed:21532592}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11278816}. Note=Mainly cytoplasmic.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10521492}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019787	small conjugating protein ligase activity
GO:0031625	ubiquitin protein ligase binding