Version 5.4
Mus musculus Protein: Fermt1
Summary
InnateDB Protein IDBP-207577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fermt1
Protein Name fermitin family homolog 1 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000047616
InnateDB Gene IDBG-207575 (Fermt1)
Protein Structure
UniProt Annotation
Function Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with filamentous actin. Constituent of focal adhesions (By similarity). Localized at the basal aspect of skin keratinocytes, close to the cell membrane (By similarity). Upon TGFB1 treatment, it localizes to membrane ruffles (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
GO:0043616 keratinocyte proliferation
GO:0051546 keratinocyte migration
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0030054 cell junction
GO:0031941 filamentous actin
GO:0032587 ruffle membrane
Protein Structure and Domains
PDB ID MGI:2443583
InterPro IPR001849 Pleckstrin homology domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR029071 Ubiquitin-related domain
PFAM PF00169
PF00373
PRINTS
PIRSF
SMART SM00233
SM00295
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P59113
PhosphoSite PhosphoSite-P59113
TrEMBL
UniProt Splice Variant
Entrez Gene 241639
UniGene Mm.209784
RefSeq NP_932146
MGI ID 4BBK
MGI Symbol Fermt1
OMIM
CCDS CCDS38248
HPRD
IMGT
EMBL AK050804 AL831763 BC029093 BC042792
GenPept AAH29093 BAC34417 CAM20382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca