InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Capn2

Summary

InnateDB Protein

IDBP-207733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Capn2

Protein Name

calpain 2

Synonyms

AI326419; Capa-2; Capa2; m-calpain; m-calpin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068895

InnateDB Gene

IDBG-207731 (Capn2)

Protein Structure

UniProt Annotation

Function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008233	peptidase activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001824	blastocyst development
GO:0006508	proteolysis
GO:0007520	myoblast fusion
GO:0016540	protein autoprocessing
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0000785	chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030425	dendrite
GO:0031143	pseudopodium
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome
GO:0097038	perinuclear endoplasmic reticulum

Protein Structure and Domains

PDB ID

MGI:88264

InterPro

IPR001300 Peptidase C2, calpain, catalytic domain
IPR002048 EF-hand domain
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family

PFAM

PF00648
PF00036
PF13202
PF13405
PF01067

PRINTS

PR00704

PIRSF

SMART

SM00230
SM00054
SM00720

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt