InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Umod

Summary

InnateDB Protein

IDBP-207933.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Umod

Protein Name

uromodulin

Synonyms

THP; Urehd1; urehr4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033263

InnateDB Gene

IDBG-207931 (Umod)

Protein Structure

UniProt Annotation

Function

Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial (By similarity). {ECO:0000250}.Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals. {ECO:0000269PubMed:14871399, ECO:0000269PubMed:15327412}.

Subcellular Localization

Apical cell membrane {ECO:0000250}; Lipid- anchor, GPI-anchor {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}. Note=Only a small fraction is sorts to the basolateral pole of tubular epithelial cells compared to apical localization. {ECO:0000250}.Uromodulin, secreted form: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007588	excretion
GO:0010033	response to organic substance
GO:0048878	chemical homeostasis
GO:0072218	metanephric ascending thin limb development
GO:0072221	metanephric distal convoluted tubule development
GO:0072233	metanephric thick ascending limb development
GO:1990266	neutrophil migration
GO:2000021	regulation of ion homeostasis

Cellular Component

GO:0000922	spindle pole
GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031225	anchored component of membrane
GO:0031410	cytoplasmic vesicle
GO:0045121	membrane raft
GO:0045177	apical part of cell
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome
GO:0072372	primary cilium