InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dvl1

Summary

InnateDB Protein

IDBP-207983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dvl1

Protein Name

dishevelled, dsh homolog 1 (Drosophila)

Synonyms

Dvl; mKIAA4029;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030948

InnateDB Gene

IDBG-207981 (Dvl1)

Protein Structure

UniProt Annotation

Function

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). {ECO:0000269PubMed:11101902, ECO:0000269PubMed:12165471, ECO:0000269PubMed:15353129, ECO:0000269PubMed:19637179}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15353129}; Peripheral membrane protein {ECO:0000269PubMed:15353129}; Cytoplasmic side {ECO:0000269PubMed:15353129}. Cytoplasm, cytosol {ECO:0000269PubMed:15353129}. Cytoplasmic vesicle {ECO:0000269PubMed:15353129}. Note=Localizes at the cell membrane upon interaction with frizzled family members.

Disease Associations

Tissue Specificity

High levels are seen in the brain, testis and kidney, lower levels in the ovary, breast, muscle, liver and small intestine, and very low levels are seen in the spleen and thymus. A moderate level expression is seen in the heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	12 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0001505	regulation of neurotransmitter levels
GO:0001932	regulation of protein phosphorylation
GO:0001933	negative regulation of protein phosphorylation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006469	negative regulation of protein kinase activity
GO:0007269	neurotransmitter secretion
GO:0007275	multicellular organismal development
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007528	neuromuscular junction development
GO:0010976	positive regulation of neuron projection development
GO:0016055	Wnt signaling pathway
GO:0021915	neural tube development
GO:0022007	convergent extension involved in neural plate elongation
GO:0030177	positive regulation of Wnt signaling pathway
GO:0031122	cytoplasmic microtubule organization
GO:0032091	negative regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0035176	social behavior
GO:0035372	protein localization to microtubule
GO:0035556	intracellular signal transduction
GO:0043113	receptor clustering
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048668	collateral sprouting
GO:0048675	axon extension
GO:0048813	dendrite morphogenesis
GO:0050808	synapse organization
GO:0060029	convergent extension involved in organogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060134	prepulse inhibition
GO:0071340	skeletal muscle acetylcholine-gated channel clustering
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005938	cell cortex
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016328	lateral plasma membrane
GO:0030136	clathrin-coated vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031410	cytoplasmic vesicle
GO:0043025	neuronal cell body
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:94941

InterPro

IPR000591 DEP domain
IPR001158 DIX domain
IPR001478 PDZ domain
IPR003351 Dishevelled protein domain
IPR008339 Dishevelled family
IPR024580 Dishevelled C-terminal

PFAM

PF00610
PF00778
PF00595
PF13180
PF02377
PF12316

PRINTS

PR01760

PIRSF

SMART

SM00049
SM00021
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt