InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dvl1

Summary

InnateDB Gene

IDBG-207981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dvl1

Gene Name

dishevelled, dsh homolog 1 (Drosophila)

Synonyms

Dvl; mKIAA4029

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029071

Encoded Proteins

IDBP-207983

dishevelled, dsh homolog 1 (Drosophila)

IDBP-627019

dishevelled, dsh homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107404:
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:155847402-155859303

Strand

Forward strand

Band

Transcripts

ENSMUST00000030948	ENSMUSP00000030948
ENSMUST00000156997
ENSMUST00000133184
ENSMUST00000141539
ENSMUST00000143457
ENSMUST00000140529
ENSMUST00000129450
ENSMUST00000168552	ENSMUSP00000133137

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	12 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0001505	regulation of neurotransmitter levels
GO:0001932	regulation of protein phosphorylation
GO:0001933	negative regulation of protein phosphorylation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006469	negative regulation of protein kinase activity
GO:0007269	neurotransmitter secretion
GO:0007275	multicellular organismal development
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007528	neuromuscular junction development
GO:0010976	positive regulation of neuron projection development
GO:0016055	Wnt signaling pathway
GO:0021915	neural tube development
GO:0022007	convergent extension involved in neural plate elongation
GO:0030177	positive regulation of Wnt signaling pathway
GO:0031122	cytoplasmic microtubule organization
GO:0032091	negative regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0035176	social behavior
GO:0035372	protein localization to microtubule
GO:0035556	intracellular signal transduction
GO:0043113	receptor clustering
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048668	collateral sprouting
GO:0048675	axon extension
GO:0048813	dendrite morphogenesis
GO:0050808	synapse organization
GO:0060029	convergent extension involved in organogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060134	prepulse inhibition
GO:0071340	skeletal muscle acetylcholine-gated channel clustering
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005938	cell cortex
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016328	lateral plasma membrane
GO:0030136	clathrin-coated vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031410	cytoplasmic vesicle
GO:0043025	neuronal cell body
GO:0045202	synapse