Version 5.4
| Mus musculus Protein: Tecpr1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-208051.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tecpr1 | ||||||||
| Protein Name | tectonin beta-propeller repeat containing 1 | ||||||||
| Synonyms | 2210010N04Rik; mKIAA1358; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000082844 | ||||||||
| InnateDB Gene | IDBG-208049 (Tecpr1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}. Lysosome membrane {ECO:0000250}. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes (By similarity). {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1917631 | ||||||||
| InterPro |
IPR000772
Ricin B lectin domain IPR006614 Peroxin/Ferlin domain IPR006624 Beta-propeller repeat TECPR IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
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| PFAM |
PF00652
PF14200 PF06462 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00458
SM00693 SM00694 SM00706 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q80VP0 | ||||||||
| PhosphoSite | PhosphoSite-Q80VP0 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 70381 | ||||||||
| UniGene | Mm.458463 | ||||||||
| RefSeq | NP_081686 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Tecpr1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS39377 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB093295 AK008701 AK169888 AK170108 BC004058 BC025567 BC046968 | ||||||||
| GenPept | AAH04058 AAH25567 AAH46968 BAB25841 BAC41478 BAE41437 BAE41568 | ||||||||