InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2j2

Summary

InnateDB Protein

IDBP-208153.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2j2

Protein Name

ubiquitin-conjugating enzyme E2, J2 homolog (yeast)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099464

InnateDB Gene

IDBG-208149 (Ube2j2)

Protein Structure

UniProt Annotation

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).In case of infection by the murid herpesvirus 4, its association with the viral E3 ligase K3 mediates ubiquitination of host surface class I (MHC-I) H-2D(b)/H2-D1 and H-2K(b)/H2-K1 molecules before they exit the endoplasmic reticulum, leading to their degradation by the ERAD system, thus blocking the immune detection of virus-infected cells. The complex formed with the murid herpesvirus 4 protein K3 mediates ubiquitination of lysine, as well as serine and threonine residues present in the cytoplasmic tail of surface class I molecules and promotes ubiquitination of hydroxylated serine or threonine residues via ester bonds instead of the classical isopeptide linkage.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:11278356, ECO:0000269PubMed:12082160}; Single-pass type IV membrane protein {ECO:0000269PubMed:11278356, ECO:0000269PubMed:12082160}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.