Version 5.4
Mus musculus Protein: Zp2
Summary
InnateDB Protein IDBP-208317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zp2
Protein Name zona pellucida glycoprotein 2
Synonyms Zp-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000033207
InnateDB Gene IDBG-208315 (Zp2)
Protein Structure
UniProt Annotation
Function The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. {ECO:0000269PubMed:22472438}.
Subcellular Localization Processed zona pellucida sperm-binding protein 2: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.Cell membrane {ECO:0000269PubMed:22472438}; Single-pass type I membrane protein {ECO:0000269PubMed:22472438}.
Disease Associations
Tissue Specificity Oocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032190 acrosin binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007339 binding of sperm to zona pellucida
GO:0060468 prevention of polyspermy
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030141 secretory granule
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID MGI:99214
InterPro IPR001507 Zona pellucida domain
PFAM PF00100
PRINTS PR00023
PIRSF
SMART SM00241
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P20239
PhosphoSite PhosphoSite-P20239
TrEMBL
UniProt Splice Variant
Entrez Gene 22787
UniGene
RefSeq NP_035905
MGI ID
MGI Symbol Zp2
OMIM
CCDS CCDS21792
HPRD
IMGT
EMBL M34148
GenPept AAA40586

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca