InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zp2

Summary

InnateDB Gene

IDBG-208315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zp2

Gene Name

zona pellucida glycoprotein 2

Synonyms

Zp-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030911

Encoded Proteins

IDBP-208317

zona pellucida glycoprotein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103310:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. [provided by RefSeq, Jul 2008]
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:120132361-120145290

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033207

ENSMUSP00000033207

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032190	acrosin binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007339	binding of sperm to zona pellucida
GO:0060468	prevention of polyspermy

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000103310

View Gene Order

ENSBTAG00000011504

Not yet available

Pathways

NETPATH

REACTOME

REACT_199082

Fertilization pathway

REACT_199085

Reproduction pathway

REACT_199072

Interaction With The Zona Pellucida pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_163933

Interaction With The Zona Pellucida pathway

REACT_163914

Fertilization pathway

REACT_163848

Reproduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P20239

TrEMBL

UniProt Splice Variant

Entrez Gene

22787

UniGene

RefSeq

NM_011775 XM_006507588 XM_006507589 XM_006507590

OMIM

CCDS

CCDS21792

HPRD

IMGT

MGI ID

MGI:99214

MGI Symbol

Zp2

EMBL

M34148

GenPept

AAA40586

RNA Seq Atlas

22787